Download PDF Handbook Of Toxicology Of Chemical Warfare Agents by Ramesh C. Gupta



Sinopsis

For centuries extremely toxic chemicals have been used in wars, conflicts, terrorists’, extremists’ and dictators’ activities, malicious poisonings, and executions. One of the earliest forms of chemical warfare agents (CWAs) were natural toxins from plants or animals, which were used to coat arrowheads, commonly referred to as ‘‘arrow poisons’’. Ancient use of some CWAs and riot control agents (RCAs) dates back to the 5th century BC, during the Peloponnesian War, when the Spartans used smoke from burning coal, sulfur, and pitch to temporarily incapacitate and confuse occupants of Athenian strongholds. The Spartans also used bombs made of sulfur and pitch to overcome the enemy. The Romans used irritant clouds to drive out adversaries from hidden dwellings. In the 15th century, Leonardo da Vinci proposed the use of a powder
of arsenic sulfide as a chemical weapon. Modern use of CWAs and RCAs or incapacitating agents dates back to World War I (WWI).

With advancements in science and chemistry in the 19th century, the possibility of chemical warfare increased tremendously. The first full-scale use of chemical warfare agents began in April of 1915 when German troops launched a poison gas attack at Ypres, Belgium, using 168 tons of chlorine gas, killing about 5,000 Allied (British, French, and Canadian) soldiers. During WWI, the deployment of CWAs, including toxic gases (chlorine, phosgene, cyanide, and mustard), irritants, and vesicants in massive quantities (about 125,000 tons), resulted in about 90,000 fatalities and 1.3 million non-fatal casualties. The majority of the deaths in WWI were a result of exposure to chlorine and phosgene gases. During the Holocaust, the Nazis used carbon monoxide and the insecticide Zyklon-B, containing hydrogen cyanide, to kill several million people in extermination camps. Poison gases were also used during the Warsaw Ghetto Uprising in 1943. Again, in November 1978, religious cult leader Jim Jones murdered over 900 men, women and children with cyanide.




Download PDF Principles of Biochemical Toxicology Fourth Edition by John A. Timbrell



Sinopsis

Toxicology is the subject concerned with the study of the noxious effects of chemical substances on living systems. It is a multidisciplinary subject, as it embraces areas of pharmacology, biochemistry, chemistry, physiology, and pathology; although it has sometimes been considered as a subdivision of some of these other subjects, it is truly a scientific discipline in itself.

Toxicology may be regarded as the science of poisons; in this context, it has been studied and practiced since antiquity, and a large body of knowledge has been amassed. The ancient Greeks used hemlock and various other poisons, and Dioscorides attempted a classification of poisons. However, the scientific foundations of toxicology were laid by Paracelsus (1493–1541), and this approach was continued by Orfila (1787–1853). Orfila, a Spanish toxicologist working in Paris, wrote a seminal work, Trait des Poisons, in 1814 in which he said toxicology should be founded on pathology and chemical analysis.

Today, highly sensitive and specific analytical methods are used and together with the new methods of molecular biology have a major impact on the development of the science. Interactions between chemicals and living systems occur in particular phases. The first is the exposure phase where the living organism is exposed in some way to the chemical and which may or may not be followed by uptake or absorption of the chemical into the organism. This precedes the next phase in which the chemical is distributed throughout the organism. Both these phases may require transport systems. After delivery of the chemical to various parts of the organism, the next phase is metabolism, where chemical changes may or may not occur, mediated by enzymes. These phases are sometimes termed “toxicokinetics,” whereas the next phase is the toxicodynamic phase in which the chemical and its metabolites interact with constituents of the organism. The metabolic phase may or may not be a prerequisite for the final phase, which is excretion.

This sequence may then be followed by a phase in which pathological or functional changes occur. Ability to detect exposure and early adverse effects is crucial to the assessment of risk as will be apparent later in this book. Furthermore, understanding the role of metabolites rather than the parent chemical and the importance of concentration in toxic effects are essential in this process. Therefore, toxicology has of necessity become very much a multidisciplinary science. There are difficulties in reconciling the often-conflicting demands of public and regulatory authorities to demonstrate safety with pressure from animal rights organizations against the use of animals for this purpose. Nevertheless, development of toxicology as a separate science has been slow, particularly in comparison with subjects such as pharmacology and biochemistry, and toxicology has a
much more limited academic base. This may in part reflect the nature of the subject, which has evolved as a practical art, and also the fact that many practitioners were mainly interested in descriptive studies for screening purposes or to satisfy legislation.



Content

  1. Fundamentals of Toxicology and Dose-Response Relationships
  2. Factors Affecting Toxic Responses: Disposition
  3. Factors Affecting Toxic Responses: Metabolism
  4. Factors Affecting Metabolism and Disposition
  5. Toxic Responses to Foreign Compounds
  6. Biochemical Mechanisms of Toxicity: Specific Examples