Download PDF Essentials of RUBIN’S PATHOLOGY SIXTH EDITION

Sinopsis

Pathology is the study of structural and functional abnormalities that are expressed as diseases of organs and systems. Classic theories attributed diseases to imbalances or noxious effects of humors on specifi c organs. In the 19th century, Rudolf Virchow, often referred to as the father of modern pathology, proposed that injury to the smallest living unit of the body, the cell, is the basis of all disease. To this day, clinical and experimental pathology remain rooted in this concept, which is now extended by an increased understanding of the molecular nature of many disease processes.

A living cell must maintain the ability to produce energy, much of which is spent in establishing a barrier between the internal milieu of the cell and a hostile environment. The plasma membrane, associated ion pumps and receptor molecules serve this purpose. A cell must also be able to adapt to adverse environmental conditions, such as changes in temperature, solute concentrations, oxygen supply, the presence of noxious agents and so on. If an injury exceeds the adaptive capacity of the cell, the cell dies. From this perspective, pathology is the study of cell injury and the expression of a cell’s pre-existing capacity to adapt to such injury.

Content

1. Cell Adaptation, Cell Injury and Cell Death
2. Inflammation
3. Repair, Regeneration and Fibrosis
4. Immunopathology
5. Neoplasia 
6. Developmental and Genetic Diseases
7. Hemodynamic Disorders
8. Environmental and Nutritional Pathology
9. Infectious and Parasitic Diseases
10. Blood Vessels
11. The Heart
12. The Respiratory System
13. The Gastrointestinal Tract
14. The Liver and Biliary System
15. The Pancreas
16. The Kidney
17. The Lower Urinary Tract and Male Reproductive System
18. The Female Reproductive System
19. The Breast
20. Hematopathology
21. The Endocrine System
22. Obesity, Diabetes Mellitus and Metabolic Syndrome
23. The Amyloidoses
24. The Skin
25. The Head and Neck
26. Bones and Joints
27. Skeletal Muscle
28. The Nervous System
29. The Eye

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