Download PDF Bacterial cellular metabolic systems

Sinopsis

Metabolism describes the overall chemical or enzymatic reactions that occur in living organisms, which assimilate nutrients with high enthalpy and low entropy and gain free energy during the process of breakdown

of nutrients into low enthalpy and high entropy substances, and thus keep the cells alive. All living organisms are in this irreversible state, and if this does not occur, the metabolic processes in the organism become in equilibrium, and the organism can no longer remain alive.

Let us defi ne the metabolite as the substrate, intermediate, or product of each metabolic reaction in the cell, and let the metabolic pathway be a series of metabolic or enzymatic reactions from the specifi c substrate to the specifi c product. Typical central metabolic pathways are shown in Figure 1.1 . When studying metabolic regulation or how cell metabolism is regulated, it is important to understand ‘catabolism’ and ‘anabolism’.

Content

1. Main metabolism
2. Brief overview of metabolic regulation of a bacterial cell
3. Metabolic regulation by global regulators in response to culture environment
4. Conventional flux balance analysis and its applications
5. C-metabolic fl ux analysis and its applications
6. Effect of a specifi c-gene knockout on metabolism

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